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The secretion of FABP4 involved unconventional pathways of EV secretion that might involve exosome-like vesicles (163), autophagic vesicles (164) and endosomal/secretory lysosomes (165)

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LEfSe is known to reduce false positives and can highlight biological consistency across subclasses, while the KruskalWallis test used alone can achieve a lower false-negative rate compared to LEfSe 38

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The panel agreed that initial treatment should be parenteral for severe cases, while high-dose oral B12 can be considered for maintenance

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